An in vitro lung biomimetic model

The design and fabrication of a system to both mimic the multicellular composition of the lung and its vascular network, as well as the composition and structure of extracellular matrix (ECM) was developed

A 3D printed collagen structure for lung in vitro models

The design of a system to model the complex structure of human lung was developed through fabrication of 3D printed collagen type I hydrogel. This model can be applied for the investigation and identification of therapeutic strategies for lung cancer

An in vitro lung biomimetic model

The design and fabrication of a system to both mimic the multicellular composition of the lung and its vascular network, as well as the composition and structure of extracellular matrix (ECM) was developed

Fabrication of extracellular matrix-like membranes for loading piezoelectric nanoparticles

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Biocompatible Electrospun Polycaprolactone-Polyaniline Scaffold Treated with Atmospheric Plasma to Improve Hydrophilicity

Conductive polymers (CPs) have recently been applied in the development of scaffolds for tissue engineering applications in attempt to induce additional cues able to enhance tissue growth. Polyaniline (PANI) is one of the most widely studied CPs, but it requires to be blended with other polymers in order to be processed through conventional technologies. Here, we propose the fabrication of nanofibers based on a polycaprolactone (PCL)-PANI blend obtained using electrospinning technology. An extracellular matrix-like fibrous substrate was obtained showing a good stability in the physiological environment (37 °C in PBS solution up 7 days). However, since the high hydrophobicity of the PCL-PANI mats (133.5 ± 2.2°) could negatively affect the biological response, a treatment with atmospheric plasma was applied on the nanofibrous mats, obtaining a hydrophilic surface (67.1 ± 2°). In vitro tests were performed to confirm the viability and the physiological-like morphology of human foreskin fibroblast (HFF-1) cells cultured on the plasma treated PCL-PANI nanofibrous scaffolds

ACTA PROCESSUS BEATIFICATIONIS MARTYRUM IN COREA

Edizione, con introduzione e studi di corredo, degli atti (in latino e in francese) del processo di canonizzazione dei martiri coreani del secolo XI

Covalent surface modification of titanium oxide with different adhesivepeptides: Surface characterization and osteoblast-like cell adhesion

A fundamental goal in the field of implantology is the design ofinnovative devices suitable foil promoting, implant-to-tissueintegration. This result can be achieved by means of surfacemodifications aimed at optimizing tissue regeneration. In the frameworkof oral and orthopedic implantology, surface modifications concern boththe optimization of titanium/titanium alloy surface roughness and theattachment of biochemical factors able to guide cellular adhesionand/or growth. This article focuses on the covalent attachment of twodifferent adhesive peptides to rough titanium disks. The capability ofbiomimetic surfaces to increase osteoblast adhesion and the specificityof their biological activity due to the presence of cell adhesionsignal-motif have also been investigated. In addition, surface analysesby profilometry, X-ray photoelectron spectroscopy, and time offlight-secondary ion mass spectrometry have been carried out toinvestigate the effects and modifications induced by graftingprocedures. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A:35-45, 200